Two-dimensional Nuclear Magnetic Resonance ( 2 D NMR) spectroscopy is widely used in chemical and biochemical analyses. Single-scan 2 D NMR: An Emerging Tool in Analytical Spectroscopy Thus, our findings may contribute to pave the way for future studies aiming at identifying important potential biomarkers for bipolar disorder diagnosis or progression follow-up. The strategy employed here showed significant potential for exploring pathophysiological features and molecular pathways involved in bipolar disorder. The data presented herein suggest that some of these metabolites differentially distributed between the groups studied may be directly related to the bipolar disorder pathophysiology. In addition, amygdalin, α-ketoglutaric acid, and lipoamide, among other compounds, were also present or were significantly altered in the serum of bipolar disorder patients. The investigated groups presented distinct metabolic profiles, in which the main differential metabolites found in the serum sample of bipolar disorder patients compared with those from controls were lipids, lipid metabolism-related molecules (choline, myo-inositol), and some amino acids (N-acetyl-L-phenyl alanine, N-acetyl-L-aspartyl-L-glutamic acid, L-glutamine). Metabolomic profiling, employing 1 H- NMR, 1 H- NMR T 2 -edited, and 2 D-NMR spectroscopy and chemometrics of human blood serum samples from patients with bipolar disorder (n = 26) compared with healthy volunteers (n = 50) was performed.
The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance ( NMR) spectroscopy and chemometrics. Sethi, Sumit Pedrini, Mariana Rizzo, Lucas B Zeni-Graiff, Maiara Mas, Caroline Dal Cassinelli, Ana Cláudia Noto, Mariane N Asevedo, Elson Cordeiro, Quirino Pontes, João G M Brasil, Antonio J M Lacerda, Acioly Hayashi, Mirian A F Poppi, Ronei Tasic, Ljubica Brietzke, Elisa Results showed H NMR and C NMR signal assignments for 2- and 3-heptanone were more challenging than for 4-heptanone owing to the…ġH- NMR, 1H- NMR T 2-edited, and 2 D-NMR in bipolar disorder metabolic profiling. NMR Analysis of Unknowns: An Introduction to 2 D NMR SpectroscopyĮRIC Educational Resources Information CenterĪ study combined 1 D (one-dimensional) and 2 D (two-dimensional) NMR spectroscopy to solve structural organic problems of three unknowns, which include 2-, 3-, and 4-heptanone.
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